Timothy Cavendish, a 65-year-old publisher, has a windfall when Dermot Hoggins, the gangster author whose book he has published, infamously murders a critic and is sent to jail. With help from the plant's head of security, Joe Napier, she evades another attempt against her life, that results in Smoke's death, and exposes the plot to use a nuclear accident for the benefit of oil companies. Isaac Sachs, another employee at the power plant who seems to find her familiar, also gives her the information, but he is killed by Smoke, who runs Rey's car off a bridge. Sixsmith tips off Rey to a conspiracy regarding the safety of a new nuclear reactor, but is killed by hitman Bill Smoke before he can give her the report that proves it.
Luisa Rey is a journalist who by chance meets an older Sixsmith, now a nuclear physicist. There, he finishes his masterpiece and shoots himself only moments before his lover Rufus Sixsmith arrives to save him. Ayrs is shot by Frobisher in a confrontation between them, and Frobisher flees to a hotel. Ayrs wishes to take credit for the piece, and threatens to expose Frobisher's scandalous background if he does not comply. Robert Frobisher, a young English musician who is gay, finds work as an amanuensis to famous composer Vyvyan Ayrs, allowing Frobisher the time and inspiration to compose his own masterpiece, the " Cloud Atlas Sextet".
When Goose attempts to administer the fatal dose, Autua saves him. Henry Goose slowly poisons Ewing, claiming it to be the cure for a parasitic worm, aiming to steal Ewing's valuables. He witnesses the whipping of a Moriori slave, Autua, who stows away on Ewing's ship, and convinces Ewing to keep him hidden, then to advocate for him to join the crew as a freeman. Adam Ewing, an American lawyer from San Francisco during the California Gold Rush, has come to the Chatham Islands to conclude a business arrangement with Reverend Giles Horrox for his father-in-law, Haskell Moore. Unlike the original novel, the film is structured, according to novelist David Mitchell, "as a sort of pointillist mosaic: We stay in each of the six worlds just long enough for the hook to be sunk in, and from then on the film darts from world to world at the speed of a plate-spinner, revisiting each narrative for long enough to propel it forward." The film consists of six interrelated and interwoven stories that take the viewer from the South Pacific in the nineteenth century to a distant, post-apocalyptic future. Action, mystery and romance weave dramatically through the story as one soul is shaped from a killer into a hero and a single act of kindness ripples across centuries to inspire a revolution in the distant future." "Cloud Atlas explores how the actions and consequences of individual lives impact one another throughout the past, the present and the future.
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